Ascaris lumbricoides is a parasite that alters the immune response of the host. This study aims to determine the serum levels of interleukin-10 (IL-10) and interleukin-22 (IL-22) in some patients and their relationships to the severity of infection. The current study also aims to study some blood parameters of patients infected with the Ascaris lumbricoides. Patients were referred to this laboratory for testing from Al Furat General Hospital in Al-Najaf Province, Al Sader General Hospital, Al-Zahra Maternity and Paediatrics, and Al-Hakeem Hospital. Formol-ether concentration and Kato-Katz thick smear techniques were used to examine stool samples. The results show a significant increase (P0.05) in serum interleukin-10 and interleukin-22 in ascariasis patients compared to the healthy group. The results revealed a significant increase (P0.05) in iron level concentration in ascariasis patients and a significant decrease (P0.05) in Hb, PCV, and RBCs count.