Biomedicine and Chemical Sciences

Mechanochemistry has recently been identified as an attractive greener method of preparing diverse molecules and has become an imperative synthetic tool in multiple fields (e.g., physics, chemistry, and materials science) because it can be performed without solvents or with minimal quantities of solvent (catalytic quantities). A variety of chemistry fields have benefited from using sustainable methods, including drug synthesis, catalysis, organic synthesis, preparation of medicinal solid forms, metal complex synthesis, etc. This review highlights the hallmarks of using mechanochemical methods to prepare multicomponent solid forms, particularly those focused on the Olanzapine drug. As a result, Olanzapine -multicomponent solid forms prepared by mechanochemical methods have many advantages over their liquid-phase counterparts in terms of yield, selectivity, short reaction times, a simpler work-up procedure, and eliminating harmful organic solvents.