Synthesis of Some New 1,3,4- Oxadiazole Derivatives and Thiazolidine Derived from Cysteine and Evaluation their Anticancer (MCF7) Activity

doi:https://doi.org/10.48112/bcs.v1i2.109

Biomedicine and Chemical Sciences

2022, Volume 1, Issue 2 : 83-87 doi: https://doi.org/10.48112/bcs.v1i2.109

Research Article

Synthesis of Some New 1,3,4- Oxadiazole Derivatives and Thiazolidine Derived from Cysteine and Evaluation their Anticancer (MCF7) Activity

Ahmed A. Majed

Dawood S Abid

DOI : https://doi.org/10.48112/bcs.v1i2.109

Published

April 1, 2022

Abstract

The study focused on the preparation of oxadiazole derivatives containing thiazolidine. Thiazolidine firstly was prepared from the reaction of benzaldehyde with L-cysteine with a good yield and then it was reacted with acetic anhydride to prepare acetyl thiazolidine, then with ethanol in the presence of H₂SO₄, then steps were taken to prepare a thiazolidine hydrazide (A₃), which was reacted with aromatic carboxylic acid in presence POCl₃ or carbon disulphide and base KOH to obtain oxadiazole derivatives A_4-8. These compounds characterized using FT-IR, NMR and Mass (EI) were diagnosed and the synthesized compound were validated. The activity of oxadiazole derivatives were studied against breast cancer cells, the two compound A₈, A₄ showed good activity against the cells as for the compounds A₅, A₆, A₇ it was showed little activity against these cells and the value IC₅₀ was calculated.

Keywords

Anticancer MCF-7

L-cysteine

Oxadiazole

Thiazolidines

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