The Genetic Polymorphisms in Polycystic Ovarian Syndrome

doi:https://doi.org/10.5281/zenodo.15776198

Biomedicine and Chemical Sciences

2024, Volume 3, Issue 3 : 77-82 doi: https://doi.org/10.5281/zenodo.15776198

Research Article

The Genetic Polymorphisms in Polycystic Ovarian Syndrome

Shakir. M. S. Alfahdawi

Aya Mohammad Muthanna

DOI : https://doi.org/10.5281/zenodo.15776198

Received

June 22, 2022

Revised

April 15, 2024

Accepted

May 5, 2024

Published

June 1, 2024

Abstract

The polycystic ovarian syndrome can be defined as an endocrine disorder that most affects the reproductive system of women of childbearing age; its causes aren't exactly known. However, the majority of the experts agree that it's a multifactorial entity with multiple factors. Genetics is becoming increasingly important. In recent years, several genes that are involved in pathogenic processes of this syndrome have been identified. Within these, the most important ones are the ones that encode for steroidogenesis enzymes and insulin receptors, as well as other hormones that are associated with the actions of insulin and gonadotropins and their receptors.

The results were obtained:

Women with PCOS had significantly lower levels of adiponectin compared to controls. Adiponectin levels were significantly lower in both lean and obese women with PCOS compared to the control group.
PCOS women had significantly higher levels of LH, FSH, LH/FSH ratio, and total testosterone compared to controls.
Both lean and obese PCOS women had significantly higher levels of LH, LH/FSH ratio, and total testosterone compared to the control group, however FSH levels were significantly increased only in obese PCOS women compared to controls.
PCOS women had significantly higher levels of total cholesterol, triglyceides, LDL cholesterol, VLDL cholesterol, and lower levels of HDL-cholesterol compared to controls.
Both lean and obese PCOS women had significantly higher levels of total cholesterol, triglycerides, LDL cholesterol, and VLDL cholesterol compared to controls. Only obese PCOS women had significantly lower levels of HDL-cholesterol compared to the controls.
The genotype analysis of FSHR gene polymorphism showed that the heterozygote Ala/Thr genotype was significantly more frequent in PCOS patients than controls (64.1% versus 40%).

Keywords

Endocrine disorder

Genetic polymorphisms

Polycystic ovary syndrome

Reproductive system of women

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