The Relation of Biomarkers in Serum Non-Alcohol Fatty Liver Disease with Diabetes Mellitus Type 2 and NAFLD Obese among Adults in Basrah Governorate

doi:https://doi.org/10.48112/bcs.v2i1.322

Biomedicine and Chemical Sciences

2023, Volume 2, Issue 1 : 16-22 doi: https://doi.org/10.48112/bcs.v2i1.322

Research Article

The Relation of Biomarkers in Serum Non-Alcohol Fatty Liver Disease with Diabetes Mellitus Type 2 and NAFLD Obese among Adults in Basrah Governorate

Fatima J. Abdul Latif

Abeer G. Al Sawafi

Dawood S. Ali

DOI : https://doi.org/10.48112/bcs.v2i1.322

Received

Oct. 2, 2022

Revised

Oct. 8, 2022

Accepted

Oct. 22, 2022

Published

Jan. 1, 2023

Abstract

Non-alcoholic fatty liver disease (NAFLD) is the term for a range of conditions caused by a build-up of fat in the liver. The goal of the study was to determine the link between lipid damage (MDA), enzymatic and non-enzymatic antioxidants, and various biochemical indicators in patients with NAFLD who had diabetes and obese adults. This study included comparison 100 patients and healthy control group, aged 18 to 75 years while BMI range from 15.9 to 50.9 Kg/m2. Enzymatic antioxidants (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx)); non-enzymatic antioxidants (GSH, vit E and direct and total bilirubin); lipid damage (malondialdehyde (MDA)), and biochemical markers (liver enzyme (ALT, AST & ALP), glucose, Albumin and lipid profile in the serum samples were measured. The NAFLD with DM and obese adult showed increasing of glucose, BMI, ALT, AST, ALP, T. CHOL, LDL, TG, VLDL, SOD and CAT levels excepted HDL. It showed a decreasing. Whereas decrease of Vitamin E and ALB levels compared to control group. Our findings show that the serum enzymatic anti-oxidant, non-enzymatic anti-oxidant, dyslipidemia and liver disfunction and vitamin E decrease are tightly and independently related to NAFLD with diabetes and obese adult status.

Keywords

Antioxidant biomarkers

Diabetes mellitus type 2

NAFLD

Obese Adult

Oxidative stress

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